The dual role of CXCL9/SPP1 polarized tumor-associated macrophages in modulating anti-tumor immunity in hepatocellular carcinoma
IntroductionThe main challenge for cancer therapy lies in immuno-suppressive tumor micro-environment.Reprogramming tumor-associated macrophages (TAMs) into an anti-tumor phenotype is a promising strategy.MethodsA comprehensive analysis by combing multi-regional single-cell, bulk and spatial transcriptome profiling with radiomics characterization wa